"Mine has been a life of much shame." Tokyo, 2036 (Showa year 111): a revolution in medical treatment has conquered death... By means of internal nanomachines and the "S.H.E.L.L." system whose network controls them, human beings suffer no diseases, require no treatment for injuries, and are guaranteed a 120-year lifespan, free from illness. Yet this consummate social system warps the Japanese nation in a host of ways: unresolved economic disparities, ethical decadence resulting from deathlessness, grave environmental pollution, and the "Human Lost" phenomenon, in which people themselves, disconnected from the S.H.E.L.L. network, become malformed. Japan teeters wildly between two potential futures: civilization's restoration or its destruction. Atmospheric pollution suffuses "Route 16" in the Outside—the area outside the Route 16 beltway. Youzou Oba, who lives an idle, drug-saturated life, joins Masao Horiki, a mysterious man who associates with the drag-racing gangs, on an incursion Inside—the area within the Route 7 loop where the privileged class lives—only to be embroiled in a violent struggle. When he encounters a malformed sufferer of the Human Lost phenomenon, a "Lost," Youzou's life is saved by Yoshiko Hiiragi, a girl of mysterious abilities who belongs to the anti-Lost agency H.I.L.A.M., and he discovers that he himself also possesses extraordinary powers... Degradation and death. Life and hope. Buffeted by fate, a man tears himself apart and cries out. Rage. Sorrow. Pathos. Consumed by despair and bitter tears, Youzou Oba is himself transformed into a demon. A human lost... or a human who can find himself?

Several months after the events of the first season, Kaiji, with his appendages reattached and his debt now run up to 9.5 million yen, is still desperately seeking the elusive big score that will cancel all of his markers. Unbeknownst to him, Hyodo’s company, the Teiai Corporation, is actively searching for Kaiji, and have sent Kaiji’s old “friend” Endoh, who entered him in the high stakes games in the past, to find him. The two meet when Kaiji chances to walk in front of Endoh’s car at a stop light, and thinking that he has found the answer to his prayers, Kaiji gets in the car with him. While Kaiji and Endoh are “happy” to see one another, and both want to see Kaiji’s debt repaid, their means to that goal couldn’t be more different. Instead of leading Kaiji to the big score, Endoh delivers him drugged and docile to the Teiai Corporation’s secret underground labor camp where Kaiji will have an opportunity to repay his debt… with 15 years of hard labor.

Having failed 19 job interviews in one day, Juri Yukawa's dreams of moving out of her parents' home are utterly dashed. Stuck living with her working mother Nobuko, NEET brother Tsubasa, laid-off father Takafumi, and single-parent sister Sanae, the only hope for this family to raise a decent adult is her little nephew Makoto. However, this struggling family's life takes a turn for the worse when Makoto and Tsubasa are violently kidnapped by a mysterious organization and held for ransom. With only 30 minutes to deliver five million yen to the criminals, Juri's grandfather reveals a dangerously powerful secret to her and Takafumi. By offering blood to her grandfather's mystical stone, the three enter the world of "Stasis," a version of their world where time stops for everyone but the users. Having arrived at their destination, their rescue efforts go awry when they are assailed by a surprising group of people who are somehow able to move around within Stasis. While all hope seems lost, a monstrous giant known only as the Herald appears amidst the chaos, its intent and motivations as cryptic as the very nature of this timeless world.

After witnessing the suicide bombing of a terrorist girl, Constable Kazuki Fuse becomes haunted by her image, and is forced to undergo retraining for his position in the Capital Police's Special Unit. However, unknown to him, he becomes a key player in a dispute between Capital and Local Police forces, as he finds himself increasingly involved with the sister of the very girl he saw die.